Getting control over nerve pain can be overwhelming; however, there are multiple ways to treat it effectively. There are innumerable prescription medicines for nerve pain that can be beneficial to get rid of nerve pain. These include pain relievers, antidepressants and anticonvulsants; however, keep in mind that all medicines won’t work for you. The healing depends upon the severity and cause of the pain. You should know all about different medications that can be effective for nerve pain treatment.
Let’s have a look at some of the nerve pain relievers in detail.

What Is the Strongest Drug for Nerve Pain?

Woman suffering from nervous neck pain

Pregabalin is an anticonvulsant drug that is in wide use for the treatment of neuropathic pain. It is one of the best prescription meds for nerve pain used to manage post herpetic neuralgia, neuropathic pain and fibromyalgia. It is an extended-release tablet that is usually taken with or without food (2-3 times a day).
Pregabalin stops seizures by lowering abnormal electrical brain activity. Furthermore, it blocks the pain by traveling through the brain and down the spine. Pregabalin also stops the brain from releasing chemicals that make you feel anxious.
To get the best advantages, you need to follow the directions on the prescription label. You can also consult with a doctor to know the best dose quantity according to your health condition; moreover, you should consider that Pregabalin may help control the symptoms but it can take weeks to get full relief from the pain.

Which Medicines Are Commonly Prescribed for Nerve Pain?

Below are some of the main types of medications for neuropathy with positive effects. Take note of this best nerve medication list for nerve pain treatment.

1) Anticonvulsants

Anticonvulsants tablets 500 mg

Anticonvulsants are the first-line prescription medication for nerve pain that help to manage seizure disorders. Different studies suggest that anticonvulsants are the most effective medicines for neuropathic pain. Also known as anti-epileptic or anti-seizure drugs, Anticonvulsants calm hyper excited nerves. Some common Anticonvulsants for treating nerve pain include:


Gabapentin is an oral solution that is ideal to control nerve pain. It is also available as tablets and capsules to relieve the pain of postherpetic neuralgia. Furthermore, Gabapentin is beneficial in treating restless legs syndrome. This prescription med for nerve pain also treats seizures. Overall, it’s effective for neuropathic pain but you should follow the medication’s expiration date guide before using it.


Oxcarbazepine is from the class of anticonvulsants. This medicine can be used separately or in combination with other medicines to control seizures in children and adults. Oxcarbazepine is an extended-release tablet to decrease abnormal electrical activity in the brain.


Carbamazepine is an effective prescription medication for nerve pain that is in use to control and prevent seizures. Furthermore, it is used to relieve trigeminal neuralgia. This medicine helps to reduce the spread of seizures in the brain and restore the normal balance between nerves.

2) Antidepressants

Antidepressants pink and purple capsule

Antidepressants are other prescription meds from the list of the nerve medication. It is believed that these are ideal to treat chronic pain by changing the nervous system activity for receptors and neurotransmitters.

Some of the medicines that come under this category are mentioned below.


Amitriptyline is used to treat mood issues by giving relief from nerve pain. Furthermore, it helps to enhance feelings of well-being. It helps to sleep better by boosting energy levels. It is from the class of tricyclic antidepressants. Such medicine won’t be available anywhere without prescription so you should know how to transfer the prescription before moving in to a newer place or traveling.


Norpramin is helpful for nerve pain treatment. It improves your mood and energy level; moreover, it is also effective to restore interest in daily life activities. It works best to restore the balance between natural brain substances. According to prescription laws in Maryland, this medicine is not recommended for children younger than 18 years.


Fluoxetine is used to treat nerve pain, panic attacks, depression and obsessive-compulsive disorder. It is the best prescription med for nerve pain in the class of antidepressants. Fluoxetine also lowers premenstrual symptoms such as depression, increased appetite and irritability.

3) Opioids

Opioids or opiates are powerful prescription medications for nerve pain. They are classified as controlled substances. Opioids block pain signals that the body sends to the brain. In this way, the brain doesn’t receive pain signals. Some of the medicines from the opioids class are listed here.


Tramadol belongs to the opioid analgesics and it is useful to get relief from moderate to severe pain. It is an effective solution to change the way body feels and responds to pain.


Methadone is an effective prescription med that changes the way the nervous system responds to pain. It is an effective prescription for those suffering from an excessive pain from surgery or injury.

What Is the Best Over-the-Counter Medicine for Nerve Pain?

Ibuprofen is one of the best over-the-counter prescription meds for nerve pain. It is related to naproxen and aspirin that are the main ingredients in Anaprox and Aleve. Ibuprofen is from the group of anti-inflammatory drugs that can be effective to relieve nerve pain, control fever and lower pain e.g. migraine, toothache and swelling caused by strains and sprains.

Ibuprofen is available in many forms including capsules, tablets, sprays and creams. Furthermore, it works by blocking the production of different natural substances that can cause nerve pain.


Nerve pain is also known as neuralgia or neuropathic pain. There are many different treatments available to treat nerve pain including topical, antidepressants, opioids and refill prescriptions. You can go to the refill prescriptions near me to get a quick refill. In some cases, health experts recommend these neuropathic meds for once and some meds are prescribed to use daily. You should always consult with a doctor to get the best dose for you.